You should keep the AO+ Restorative Mist refrigerated until you first start using it. Once you start using the product, you can keep it at room temp, somewhere convenient like your bathroom counter, for example. After 4 weeks at room temperature, the bacteria start to lose activity. Think of the refrigerator as a way to pause or slow down the loss of activity. You’re welcome to keep the AO+ Restorative Mist in the fridge even after you begin using it in order to stretch the life of the product beyond 1 month.